Virtual Screening and ADMET Studies of Phytomolecules Targeting DNA Topoisomerase II
نویسندگان
چکیده
منابع مشابه
Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II
The reaction mechanism of DNA topoisomerase II (TOP2) involves a covalent double-strand break intermediate in which the enzyme is coupled to DNA via a 5'-phosphotyrosyl bond. This normally transient enzyme-bridged break is stabilised by drugs such as mitoxantrone, mAMSA, etoposide, doxorubicin, epirubicin and idarubicin, which are referred to as TOP2 poisons. Removal of topoisomerase II by the ...
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در این مطالعه بر هم کنش این چهار کمپلکس با dna تیموس گوساله توسط روش های اسپکتروفتومتری، فلوریمتری، دو رنگ نمائی دورانی، و ویسکوزیمتری بررسی شدند تا اثر استخلاف های متیل بر روی لیگاندهای فنانترولین بررسی گردد.
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ژورنال
عنوان ژورنال: Indo Global Journal of Pharmaceutical Sciences
سال: 2017
ISSN: 2249-1023
DOI: 10.35652/igjps.2017.55